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On The Forefront.

Minocycline protection of hearing loss in gerbils treated with neomycin"

Alan Robinson, Ph.D. at Northwestern University has successfully protected hearing due to aminoglycoside transtympanic injection using minocycline treatment of gerbils. Findings were presented at the 2010 Association for Research in Otolaryngology (ARO) conference in Anaheim, CA. Check back here in Spring/Summer 2010 for the manuscript which is currently in preparation.

news & events mission, vision & values grant application information support research links & resources special thanks funded research donate airline miles new! chalkboard - write about your research or interests. The Capita Foundation Auditory Research (CFAR) grant cycle has closed for 2010. Click on the grant application link above for more information. Check out our Pages: Support Research Today:	ASL Integrated in West Coast opera premiere (2010) Grant Recipient Makes Top 10. Paper by Capita Foundation Auditory Research grant-funded research scientist Peter A. Santi and colleagues was listed as one of the top 10 in 2009 for BioTechniques. Details: Thin-sheet laser imaging microscopy for optical sectioning of thick tissues Peter A. Santi1, Shane B. Johnson1, Matthias Hillenbrand2, Patrick Z. Grandpre1, Tiffany J. Glass1, James R. Leger3 BioTechniques, Vol. 46, No. 4, April 2009, pp. 287–294 A movie showing TSLIM optical sectioning of the zebrafish head and 3D reconstruction of its inner ear. For further information contact: Dr. Peter Santi. In this report, Drs. Santi, Johnson, Hillenbrand, Grandpre, Glass and Leger report the development of a modular and optimized thin-sheet laser imaging microscope (TSLIM) for nondestructive optical sectioning of organisms and thick tissues such as the mouse cochlea, zebrafish brain/inner ear, and rat brain at a resolution that is comparable to wide-field fluorescence microscopy. TSLIM optically sections tissue using a thin sheet of light by inducing a plane of fluorescence in transparent or fixed and cleared tissues. Moving the specimen through the thinnest portion of the light sheet and stitching these image columns together results in optimal resolution and focus across the width of a large specimen. Dual light sheets and aberration-corrected objectives provide uniform section illumination and reduce absorption artifacts that are common in light-sheet microscopy. Construction details are provided for duplication of a TSLIM device by other investigators in order to encourage further use and development of this important technology. Introduction The ability to selectively visualize three dimensional (3-D) biological structures is useful for understanding structure, function, and dysfunction relationships in tissues and organs, and is one of the initiatives of the National Institutes of Health (NIH) Roadmap for Medical Research. Click here for full text (PDF)	What Makes Us Different? The Capita Foundation is one of the few nonprofit organizations *specializing in the support of cutting-edge auditory research worldwide*. Our grants provide seed money to scientific researchers with significant vision, but little or no financial support. These grants not only ensure that innovative projects move forward, but help researchers leverage additional grants to continue critical research. Learn more about the Capita Foundation
		On The Forefront. Minocycline protection of hearing loss in gerbils treated with neomycin" Alan Robinson, Ph.D. at Northwestern University has successfully protected hearing due to aminoglycoside transtympanic injection using minocycline treatment of gerbils. Findings were presented at the 2010 Association for Research in Otolaryngology (ARO) conference in Anaheim, CA. Check back here in Spring/Summer 2010 for the manuscript which is currently in preparation.
Research Supported by Capita: 2009 CFAR Grant Recipients Karen A. Doherty, Ph.D. "Improving communication for older hospital patents with assistive listening devices" Avril Genene Holt, Ph.D. "Control of Auditory Neurons via Light Gated Channels following Deafness" Zheng-Yi Chen, D. Phil. "Identification and analysis of inner ear stem cell genes" Derron Herr, Ph.D. "Exploring new modalities for the treatment of hearing loss thru the study of SIP signaling" Monika Kordus, Ph.D. "Improving Binaural Fitting Procedures of Hearing Aid and Cochlear Implant through Loudness Judgments throughout the Dynamic Range" Lisa Goodrich, Ph.D. "Rewiring the Cochlea: A Genetic Screen for Regulators of Auditory Circuit Assembly" Previously Funded Projects Michael J. Epstein, Ph.D. "Automated procedures for the estimation of individual loudness-growth functions for improved hearing-aid fitting" Victor Pikov, Ph.D. "Tinnitus - related pathophysiology in the cochlear nucleus" Joseph Donaher, Ph.D. SANDBOX" (Simulated Activities of Naturalistic Disclosure) Kevin Frank, Ph.D. "Testing the perceptual limits of acoustic and electric hearing in children using cochlear implants" Clause-Peter Richter, Ph.D. "The current distribution in the cochlea and coding of acoustic information" Alan M.Robinson, Ph.D. "Inhibition of apoptosis as a means to mitigate hearing loss in mice" Peter Santi, Ph.D. "High Resolution Imaging of the Cochlea in an x-Linked Alport Mouse Model" Paul Webster, Ph.D. "Identifying and Treating Biofilm Infections Associated with Otitis Media"
		CFAR grants recipients for 2010 will be announced here on October 1st. for information on how to apply for funding click here.
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	Thanks to our Community Partners. Sound+Vision San Diego 2010 has concluded. In an effort to promote public awareness about hearing health the Capita Foundation in conjuction with its many Community Partners staged concerts and lectures during the month of May. Without these Community Partners many of these programs would not have been possible. We encourage you to visit our Sound+Vision page for more information on these partners and this valuable program.	Email Newsletter – Subscribe Now! email address:
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